Tuesday, August 30, 2011

This is me

This is me going to sleep too late.
And waking up too early.

Please let me wake up on time so I'm not late for work

6:30 in the morning

I still don't get why Humboldt needs sushi at 6:30 AM on Tuesdays.
I certainly don't.

Thursday, August 25, 2011

The Genetic Basis of Cancer

the banjo i sold by water your plants

Cancer is caused by mutations in Genes. Cancer is mostly a disease for the aging due to an increased number of genetic mutations over time. When clonal proliferation occurs, a single cell with a mutation has an increase growth rate as well as a decreased death rate. With a faster accumulation of this specific mutated cell, it could become an early stage of a tumor. With more and more of the mutated cell, a normal to fully malignant cancer can develop.

There are different types of Gene Mutations in Cancer such as: alteration of progrowth and antigrowth signals, angiogenesis, and telomeres and immortality. For a cancer cell to become fully malignant the cell must be able to grow without needing external growth signals. Some cells stimulate their own growth with autocrine stimulation and some cancers increase their growth factor receptors. Many cancers have an activating mutation in their ras, or their intracellular signaling protein. This 'mutant ras' stimulates growth even when growth factors are lacking. The antigrowth signal must be inactivated in cancer as well as being able to grow without growth factors. Advanced cancers must overcome apoptosis by disabling the self-destructing mechanism. To maintain an advanced cancer or grow a small cancer, angiogenesis is needed. Angiogenesis is the development of blood vessels in order to deliver oxygen and nutrients. Telomeres and immortality is another component to gene mutation in cancer. Cancer cells somehow activate telomerase to restore and maintain there telomeres, protect their chromosomes, and sometimes develop the ability to divide repeatedly.

Oncogenes are mutant genes that in their normal non-mutant state direct synthesis of proteins that positively (accelerate) regulate proliferation. Tumor-suppressor genes encode proteins that are in their normal state negatively (put the brakes on) regulate proliferation. Mutations that create oncogenes are: point mutations, chromosome translocations, and chromosome amplification. A point mutation is the alteration of one or a few nucleotide base pairs. Chromosome translocations can activate oncogenes by either causing an excess and inappropriate production of a proliferation factor or by leading to production of novel proteins with growth-promoting properties. Chromosome amplification is the result of duplicating a small piece of a chromosome over and over again so that there are way too many copies.

When tumor suppressor genes, such as retinoblastoma (Rb) genes are inactivated, cell division is no longer inhibited and the cell can divide and can continue without any disruption. Point mutation can inactivate Rb on a cell's chromosome. When this happens the tumor suppressor will continue to be inactivated in newly made cells. The loss of heterozygosity is the loss of a chromosome region in a tumor and this unmasks mutations in recessive tumor suppressor genes. Gene silencing doesn't require mutations or changes in the DNA sequence, it is an important way to inactivate tumor suppressor gene expression in cancers. When taking mutations into account, the ways the genetic information can be compromised are: during each round of DNA synthesis, during each mitosis when chromosomes are segregated to daughter cells, and when external mutagens alter or disrupt DNA. When chromosome instability is ongoing in certain recessive traits malignant cells are increased due to the acceleration of the loss of tumor suppressor genes and the overexpression of oncogenes. Cancers that are inherited are due to the mutated cell being in the germ line, mutated somatic cells are not inherited. With the characterization of cancer-causing genes and other genetic factors, we can identify and help treat in earlier stages rather in the later stages.

By Meredith Hunt


Works Cited:
Huether, S. , McCance, K. , Brashers, V. , & Rote, N. (2008). Understanding pathophysiology. (4 ed., pp. 228-235). St. Louis: Mosby Elsevier.

Monday, August 22, 2011

a good time

my spinning set-up by water your plants
Just happened to be in the right place at the right time.
Borrowed spinning wheel, Free roving.

Friday, August 12, 2011

Ebay Bidding War

What the heck. I hate bidding wars. This is ridiculous. I mean I guess I could just spend the next day and 38 minutes out-bidding Mr. 1***c  ...but I've got shit to do. Hopefully I can remember to come back in time for the end 38 minutes.

Wednesday, August 10, 2011

The Flashcard Method.

I write all my options on separate flashcards and on the back of each flashcard I write the pro's and con's for that particular option. Then I tally up the number of pro's and con's for each option and which ever one has the least amount of con's and the most amount of pro's is the winner. And that's how I make my life decisions when I have no idea what to do. Sometimes if I don't like the end result then it helps me realize I do have an idea on what to do, then I have my answer. So I'm off to do laundry and then I'll get a coffee at the Ramones on Harrison and figure this whole thing out, with my flashcards.

Went through my closet

Escot Farms by water your plants
Went through my closet today and got rid of almost half of everything. I have a bunch of laundry to do that I didn't account for, so tomorrow after I do my laundry I'll try to split the clean laundry in half. Half my closet is already empty now and everything I'm giving away is in a big pile in front of my bedroom door. I don't really have furniture so I think I'll just stick with trying to get rid of half my clothes, shoes, and jewelry. I don't have much jewelry either so I don't think that will be too hard. Surprisingly, it wasn't difficult at all to find things to get rid of. I think it took me about five minutes to pull half of my closet apart.

I plan to donate anything I can't sell to the Betty Chin fund, she said she always needs clothes and shoes so I don't think she'll turn down any of my clothes if I have any left. All the money I do make off my clothes (probably won't be much) I plan to donate to charitywater.org which is a non-profit organization bringing clean and safe drinking water to developing nations where 100% of donations go directly to the field to fund water projects.

Luke3:11
"Have2Give1" experiment -Mark Scandrette

Monday, August 8, 2011

rad trinidad

rad trinidad  by water your plants

Simplifying

DSC_0032 by water your plants
Started reading this book. It's challenging. One of the challenges is simplifying your life. So I'm looking at every aspect of my life and shrinking it down as much as possible. My bed doesn't have a stand anymore. And tomorrow I'm getting rid of literally half of my belongings. Except my knitting needles, that would be insane.

Friday, August 5, 2011

Spinning

Spindle of my first yarn and rovingSpindle of my first yarnSpindle of my first yarnSpindle of my first yarnSpindle of my first yarnSpindle of my first yarn
Spindle of my first yarnSpindle of my first yarnSpindle of my first yarn


Spinning, a set on Flickr.
My wonderful new friend let me borrow one of her spinning wheels! So for the past few days I've been spinning away in my room. I absolutely adore it. However, plying is challenging when no one is helping you with the pedaling.

Wednesday, August 3, 2011